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MB can cause a rise in blood pressure and peripheral vascular resistance, and it may reduce regional blood flow (for instance, caution is needed in patients with pulmonary hypertension or compromised circulation because MB could potentially worsen those by opposing NO-mediated vasodilation)

A case report of seizure induced by bupropion nasal insufflation

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Arachidonate lipoxygenase 15 (ALOX15), a member of the ALOX family, has the potential to facilitate the production of lipid peroxidation (64)

Additionally, controlled release reduces the likelihood of high concentrations of antioxidants being released at once, which could be damaging