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Diabetes Obes Metab 25(1):5667 Rosenstock J, Wysham C, Frias JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

HFLT most often occurs in the foot and ankle region of middle-aged adults (median age: 51)

Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

No, Sermorelin boosts growth hormone levels

About 15% of patients are non-responders, often due to concurrent nutrient deficiencies (like magnesium or folate) that require additional supplementation for full therapeutic effect