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What Phase 2 Data Tells Us to Expect The Phase 2 trial of retatrutide, published in The New England Journal of Medicine in 2023, provided an unusually clear preview of what TRIUMPH-1 might deliver

The LEADER trial for liraglutide and the SUSTAIN-6 trial for semaglutide both showed significant reductions in major adverse cardiovascular events in high-risk patients

That standard is unfortunately not universal, as many unlicensed peptides originate from laboratories in China and India with little to no traceability

While cardiovascular outcome data for retatrutide is still accumulating, the prudent approach for anyone with active cardiovascular disease is to remain on compounds with established cardiovascular safety profiles

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