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Research has characterised MT-II-induced anorexia in rodent feeding paradigms , examining food intake suppression kinetics, meal pattern changes, body weight effects with repeated administration, and the hypothalamic neurochemical changes including NPY/AgRP suppression and melanocortin pathway activation markers accompanying MT-II-induced anorexia

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A insuficincia adrenocortical acompanhada por perda de peso, nusea, desidratao, diarreia, vmito e hipotenso

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The results were compared with a potent CB1 inverse agonist (AM251) administered orally at 10 mg/kg once daily or 5 mg/kg twice daily as a positive control