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Dordrecht: Kluwer

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10.3389/fpsyt.2021.813590 129

However, in some instances, paradoxically, binding of the antibodies at subneutralizing concentrations to non-critical sites of the virion can result in non-neutralization of the virion that may lead to virion entry and invasion into certain cell types via antibody Fc region present on the carboxyl-terminal domain of antibody with Fc gamma receptor IIa (FcRIIa)-expressing phagocytic cells like the monocytes, macrophages, or through interaction with complement receptors contributing in the enhancement of infection, a process known as antibody-dependent enhancement 37,38,39,40,41 during these instances, the binding of antibodies to these non-critical sites leaves the virus with retainment of its infectivity 37