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The inhibitory effects of IGF-1 on IL-1-induced NF-B activation are partially mediated by inhibiting the Src/PI3K/AKT pathway [29]

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More recently, encouraging clinical results from a triple-hormone-receptor agonist, Retatrutide, and several GLP-1R/GCGR dual agonists, suggest that GCGR could be a promising co-stimulating target for type 2 diabetes and obesity.