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Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)

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In some of the trials, we saw that individuals who had those variants were unable to lower their blood glucose levels as effectively after six months of treatment, said Anna Gloyn, DPhil, professor of pediatrics and genetics and a senior author of the study