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Epidemiological studies estimate that the global prevalence of overt hypothyroidism is approximately 4.6% in the United States and 5% in Europe, with even higher rates observed in iodine-deficient regions (Persani, 2012)

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[DOI] [PubMed] [Google Scholar] Neubauer C, Yamamoto HY

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Thus, the disruptions of the kidney-brain axis contribute to the high morbidity of neurological disorders, such as cognitive impairment in CKD (Yan et al., 2024)

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Switching to 2.0 mL or even 1.0 mL of water for subsequent vials brings the unit count back into a manageable range

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