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Commonly discussed side effects in this medication class may include nausea, vomiting, constipation, diarrhea, reflux, abdominal discomfort, reduced appetite, fatigue, dehydration risk, and food aversions

The core principles haven't changed from what works with current GLP-1 medications

Back DiMarchi, R Efendic, S (1997) 'Use of GLP-1 analogs and derivatives administered peripherally in regulation of obesity', US Patent US6191102B1.Back Drucker, DJ, Habener, JF, Holst, JJ (1 Dec 2017) 'Discovery, characterization, and clinical development of the glucagon-like peptides', Journal of Clinical Investigation , 127/12, 4217-27

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Yet many people with excess weight dont take the shots due to cost, spotty insurance coverage and fear of needles. The oral formulation expands treatment options for patients who have avoided injectable GLP-1 therapy