The exact cause of neuronal death in Parkinson's remains incompletely understood, but contributing factors include oxidative stress, mitochondrial dysfunction, neuroinflammation, and abnormal protein aggregation (particularly alpha-synuclein)
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Patients undergoing GLP-1 RA therapy who adopt unstructured reductions in dietary intake should be closely monitored for gut microbiome dysbiosis, as preservation of gut microbiome eubiosis is foundational to health