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Potential modulation of central pain processing through GABAergic effects

Ta Park VM, Ly Q, von Oppenfeld J, et al

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The no-observed-adverse-effect level (NOAEL) was established at 0.03 mg/kg/week in rats and 0.02 mg/kg/week in monkeys, corresponding to systemic exposures approximately 5- to 8-fold higher than human therapeutic levels