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Besides podocytes, berberine can also upregulate the expression of CPT1 and PPAR in renal TECs, further improving mitochondrial FAO and reducing lipid accumulation in DKD mice (Rong et al., 2021)

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Whether it does so intelligently depends on the quality of IP, regulatory, and commercial intelligence being applied

Its actual consequence is the creation of a 100-million-person consumer cohort whose skin biology, hair cycle, gut microbiome, and behavioural relationship with beauty products have been fundamentally and predictably restructured by a single pharmaceutical class