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These include: Tier 2 services : Community-based lifestyle interventions Tier 3 services : Specialist multidisciplinary teams for complex obesity Tier 4 services : Bariatric surgery assessment and procedures Referral criteria for these services are outlined in NICE guideline CG189 for obesity management

Therefore, the inhibition of SGLT2 may reduce the activity of URAT1 by enhancing luminal glucose transmission or lowering insulin levels, or SGLT2 and URAT1 may functionally interact in the proximal tubule, thereby inhibiting SGLT2 to partially suppress URAT1 (Novikov et al., 2019

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