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For elective operations, the UKCPA Perioperative Medicines Handbook and CPOC guidance generally advise that weekly GLP-1 receptor agonists can be continued before surgery with standard fasting protocols, though individualisation is recommended for patients with significant gastrointestinal symptoms or those at high risk of aspiration

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Analysis of mRNA from the aortas of different groups showed that FOXO4-DRI effectively inhibited the increase of pro-inflammatory factors such as Il-1 , Il-6 , Cxcl15 , and Tnf- (Figure 2B)