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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

Temperature excursions above 77 degrees Fahrenheit cause accelerated degradation of the peptide

(Lausanne) 11 , 622589 (2020)

As of TBD Annualized Performance Annualized Performance The performance data quoted represents past performance