Early studies found no significant effect of intravenous GIP on bone resorption, 10 whereas more recently, GIP infusion was shown to suppress the bone resorption marker CTX-I and transiently increase the bone formation marker P1NP in people with T1D as well as healthy controls
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1Model based estimates based on an analysis of covariance model including treatment and type 2 diabetes status as factors and baseline value as a covariate 2Not included in the pre-specified hierarchical testing 3Model based estimates based on a mixed model for repeated measures including treatment and type 2 diabetes status as factors and baseline values as a covariate 4Baseline value is the geometric mean Overview of Clinical Trial in Pediatric Patients WEGOVY was evaluated in a 68-week, double-blind, randomized, parallel group, placebo-controlled, multi-center trial in 201 pubertal pediatric patients aged 12 years and older with BMI corresponding to 95th percentile standardized for age and sex (Study 7) (NCT#04102189)
Correct placement ensures slow, steady absorption into the bloodstream
Some emotional volatility might be caused by excess heat in the heart and liver, reflecting a history of liver/heart fire
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