Ketamine and psilocybin each produce a brief acute experience but set off a wave of synaptic growth afterward, ketamine through glutamate release and mTOR-dependent synapse formation and psilocybin through rapid, lasting growth of dendritic spines in the frontal cortex, both via BDNF signaling, which is why a single session can shift symptoms for weeks
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Whether those studies establish a sufficient benefit-risk profile for human use through compounding pharmacies was the core scientific question, and the committee's majority answered yes over the objections of FDA scientists who answered no

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