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The temperature was set at 310 K, using a thermostat damping of 0.1 ps 1 and the M-SHAKE algorithm 53 to constrain the bond lengths involving hydrogen atoms

This makes sense since the liver filters out most medications and toxins

*Correspondence: Kazuki Saito, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan e-mail: [email protected] This article was submitted to Plant Physiology, a section of the journal Frontiers in Plant Science

Improved efficacy of dutasteride (0.5 mg/day) over finasteride (5 mg/day) in terms of symptom score, maximal urinary flow rate and quality of life had also been published by Kumar, et al

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