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al "From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin-like (Ubl) Proteins. In this work, we provide a comprehensive chemical biology perspective on how activity-based probes, fluorogenic substrates, proximity labeling, and emerging live-cell reporters are transforming the way Ubiquitin and Ubl signaling pathways are studied