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CrossRef Treatment of type 2 diabetes mellitus - a current view of the different drug classes and strategies for their use Jan Bro Vnitn lkastv.2025

Kidney function significantly affects exenatide and lixisenatide clearance, but medications like semaglutide, tirzepatide, dulaglutide, and liraglutide undergo proteolytic degradation and do not require renal dose adjustments

Moreover, GLP-1RAs have been shown to exert many beneficial effects on vascular endothelial cells

This concern relates to a common physiological principle known as down-regulation , where the body reduces its sensitivity to a hormone when it receives a strong external signal for an extended period