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Scientific interest often centers on cellular signaling, cytoskeletal organization, actin regulation, angiogenesis-related pathways, and extracellular matrix biology

3 In the REIMAGINE 1 trial, the most commonly reported adverse events (AEs) were gastrointestinal (GI)-related, occurring in 33/62 (53%) participants in the CagriSema 2.4 mg/2.4 mg group, 28/63 (44%) participants in the CagriSema 1 mg/1 mg group, and 13/64 (20%) participants in the placebo group

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The 15 mg/kg dose is massive when translated to a human protocol

DJH and BRR receive financial support from the Australian Research Council Linkage Projects scheme (LP140100095)