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Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
C.Di NapoliR
This may reflect changes in sleep stage cycling rather than a direct effect on REM content
A vial pulled from the freezer, partially used, refrozen, and pulled again has experienced multiple freeze-thaw cycles that progressively damage the peptide structure, as noted in Bachems pharmaceutical handling and storage guidelines for peptides, which outline how thermal cycling degrades peptide integrity at the molecular level even before visible changes occur
Diabetes Care 43 , 964974 (2020)
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