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One early application involved training five ML models on 545 publicly available skeletal muscle transcriptomes to predict donor age, with the Deep Feature Selection model achieving a mean absolute error of 6.24 years, followed closely by a Support Vector Machine model

These AG 538 bioisosteres possessed similar but weaker biological properties to AG 538 but are more stable and blocked the formation of colonies of prostate and breast cancer cells in soft agar systems (Blum et al, 2003)

These results indicate that the administration route of shikonin has a significant impact on its toxicity level

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