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The immune cells in TME are mainly immunosuppressive cells with the progression of tumors, such as M2 TAMs, MDSCs, N2 TANs, and regulatory T cells (Tregs), while the number of anti-tumor immune cells decreases and their functions are suppressed, such as DCs, NK cells, M1 TAMs, and N1 TANs, which leads to tumor progression and recurrence due to tumor cells evading the surveillance of the immune system (5)

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