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Ethics declarations Ethics approval and consent to participate All animal experiments were conducted after approval from the Institutional Animal Care and Use Committee of the Tongji Medical College, Huazhong University of Science and Technology, and all procedures were in compliance with the relevant guidelines and regulations of the Chinese Council on Animal Care

In terms of evaluating prediction accuracy of specific medical codes, we found that all of the models including GRAM and Doctor AI do not perform well on the low-frequent medical codes (with median accuracies equal to 0 and mean accuracies below 25% accuracy range), and the accuracy estimates are unstable for the rare medical codes, depending on the training and testing split

Cost: This is because the established techniques of developing and manufacturing nanomedicines could be costly impacting their availability

Infinite Health IMC.

The intranasal spray format removes the need for mixing, removes syringe and needle consumables from research workflows, and removes injection-site tissue artifacts that can complicate histological test in longitudinal studies