DBP: Diastolic Blood Pressure
After being secreted into the bloodstream, GLP-1 is rapidly degraded and inactivated by dipeptidyl peptidase-4 (DPP-4), with a half-life of only 2 minutes in the body, which limits its application in glucose-lowering therapy
[67] studied a cohort of over 400,000 T2DM patients above the age of 65 and found that DPP-4i were associated with a 21% decrease in the risk of MACEs (including myocardial infarction and ischemic stroke) with a 46% overall decrease in risk of all-cause mortality
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Perhaps most impressively, GHK-Cu completely blocks copper-dependent oxidation of LDL cholesterol, while superoxide dismutase (SOD1) provides only 20% protection in the same comparison