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Optimised Absorption: Even with malabsorption, theres a small amount of B12 that can be absorbed passively at very high oral doses

Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders

When you expose your receptors to any signaling molecule continuously, they gradually become less responsive a process called receptor downregulation

The most common early indicator is reduced shedding

however, given the limited vascular supply to the inner meniscus, and hence healing abilities, injuries there usually require resection of the damaged tissue