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GLP-1 stands for glucagon-like peptide-1, a gut hormone released in response to eating that serves as a satiety signal, stimulating insulin release, inhibiting glucagon secretion and regulating gastric emptying

doi: 10.2147/DMSO.S229802 36 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFNauckMAet al

Similarly, a high-fat diet has been shown to induce dysbiosis in gut microbiota, subsequently leading to reduced expression of mucus and tight junction proteins in the colon, triggering local and systemic inflammation [109, 110]

Tomas E, Wood JA, Stanojevic V, Habener JF

Drucker agreed that these newer drugs do not meaningfully penetrate the brain, but Secher, Rinaman, and others have shown they do meaningfully signal to many regions deep within the brain