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Although stomach or gastrointestinal side effects are common, theyre usually mild

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It means there is no established dosing standard, no agreed safety profile for reproductive use, and no clear proof it helps fertility outcomes

Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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