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The efficacy and safety of canagliflozin 100 mg and 300 mg have been demonstrated in an extensive clinical development programme that included cardiovascular and renal outcomes trials (CANVAS, CANVAS-R and CREDENCE) [22, 23]

However, genetic variants in GLP-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) genes influence how strongly an individual's gut responds to these medications, explaining why some tolerate them better than others

Medications are shipped directly from third-party, FDA-approved, U.S.-based compounding pharmacies.

Thats why it is available in three different concentrations

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