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If facial change during rapid weight loss is measurable, predictable per kilogram, and concentrated in a specific tissue layer, then the timing of a treatment plan becomes a real clinical variable rather than an afterthought

Kantarjian H, Manshouri T, Talpaz M, OBrien S, Keating M, Cortes J, Pierce S, Andreeff M , Kornblau S, Albitar M

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Understanding these mechanisms helps clinicians select the most appropriate GLP-1 agonist for individual patients and set realistic expectations regarding tolerability