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Oral therapies for pulmonary arterial hypertension: endothelin receptor antagonists and phosphodiesterase-5 inhibitors

Building upon our previous work using proteolytically activated hydrogels [1419], we envision using fusion proteins to release therapeutic proteins in response to disease-specific proteases

While oral formulations exist, they work best for gastrointestinal applications

Materials PEG ( M n = 6000 g mol 1 ), MDI, IU, DBTDL, DMF, DPPH (2,2-diphenyl-1-picrylhydrazyl) and TA were purchased from Aladdin (Shanghai, China)