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In 2019 and 2020, a formulation of Semaglutide (brand name Rybelsus) was approved as a daily oral medication for treating diabetes, when used along with diet and exercise

This is the shared mechanism across the entire class and the primary reason all three compounds reduce caloric intake

Continuous GLP-1 Therapy as a Long-Term Solution Rather than treating GLP-1 therapy as temporary, evidence increasingly supports viewing it as ongoing management for weight and metabolic healthsimilar to how people manage blood pressure or cholesterol with continuous medication

Neurobiol Dis 124:505519

While discussing weight can be uncomfortable, the sooner patients and providers begin talking about treatment, the earlier we can intervene to improve their health