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When symptoms do appear, they are often vague and easily overlooked: Because obvious symptoms are often absent, the condition is frequently discovered accidentally during blood tests (showing elevated liver enzymes) or imaging scans (such as ultrasounds or CT scans) performed for other reasons

We have shown that CuCl 2 and Cu(OAc) 2 irritation induces the upregulation of various genes without the concomitant inhibition of cell viability

DiMaggio, et al., Updates in Infant Nutrition, Pediatrics in Review, October 1, 2017 Tracy P

However, intracellular GSH at high concentrations inactivates ROS and reduces efficacy

Huang, Q