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Christensen LL, Selman C, Blount JD, Pilkington JG, Watt KA, Pemberton JM, et al

Hepsin levels remained stable at 0.5 h post-treatment with 400 mg/kg APAP, comparable to those in saline-treated control livers

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CHB is also characterized by T-cell exhaustion, which is worsened by alcohol and includes up-regulation of PD-1, CTLA-4, and TIM-3 (66), impaired mitochondrial function in T cells (67), and impaired antigen-presenting function of dendritic and Kupffer cells (6870)