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The most frequently reported side effects in clinical trials were gastrointestinal in nature, including nausea (occurring in up to 44% of patients taking Wegovy at the 2.4 mg dose), vomiting, diarrhea, abdominal pain, and constipation

A subsequent Japanese survey ( N = 500) also assessed the willingness of patients with T2D to initiate different GLP-1RA therapies based on unbranded therapy profiles

The majority of patients see burping and gas improve within 48 weeks as their digestive system adjusts to the medication's effects

Persico, A.M

Of these, GLP-1 RAs are generally preferred because of their demonstrated cardiovascular benefits and potential for improved renal outcomes [2]