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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia

To further evaluate the effect of eye drops on the metabolomic profile of the aqueous humor, we performed association analyses with and without eye drops (Supplementary Table 4)

Holtzman et al., 2012)

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And that's because the innervation, the number of wires that go into those regions of your body, far exceeds the number of wires for sensation of touch that go to other areas of your body