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Sustained high blood sugar levels can lead to glutathione depletion, causing oxidative stress and tissue damage

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Since glutamate is one of the brains major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven

Among these are insulin resistance, elevated levels of low-density lipoprotein (LDL) cholesterol and hyperuricemia, which is an excessive buildup of uric acid