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GLP-1R expression spans multiple neuroanatomical domains including the basal ganglia (caudate, putamen, globus pallidus), limbic system (amygdala, hippocampus), hypothalamic nuclei, cerebellum, and spinal cord 69

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While they both promote insulin release, the GLP-1 receptor reduces the release of another hormone made by the pancreas called glucagon, which balances the effects of insulin on blood sugar, while the GIP receptor promotes glucagon release

This article explains how they work, who can use them, their benefits, side effects, and how they compare with other diabetes treatments

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