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While little data is available on Exendin-4, the GLP-1 agonist most similar in structure to it, Exenatide (Byetta), undergoes minimal enzymatic metabolism

Splitting into morning and evening doses helps maintain consistent levels

A phase 3 2021 clinical trial found the mean weight loss on 2.4 milligram weekly injections of GLP-1 was 14.9% versus 2.4% with placebo after 68 weeks among people with a body mass index (BMI) of 30 or greater

Pagali has received the Mayo Clinic CTSA (Mayo Clinic Small grants) through grant number UL1TR002377 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH)

Current evidence suggests NMN might work better than NAD+ because it's more bioavailable and converts directly to NAD+