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152 Mechanically, the GnRH agonists induce sustained stimulation of the pituitary gland to induce the downregulation and desensitization of GnRHR, resulting in the reduction of LH release and suppression of testosterone production to castration levels

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However, both insulin resistance and hyperinsulinemia can contribute to cognitive impairment in adults, highlighting impaired tissue sensitivity to insulin as a pathogenic mechanism in AD [29]

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