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Sanjay Kaul, a frequent FDA advisor, pointed out the paradox of the large commercial success of the diabetes drugs despite the absence of any proven clinical benefit: "So, we have a drug that yields modest glycemic efficacy, is neutral with respect to cardiometabolic factors (lipids, weight, blood pressure), does not kill you or land you in a hospital, and yet is a blockbuster drug nearly 5 times over

Gastrointestinal Side Effects : Common side effects include nausea, vomiting, and diarrhea, especially during dose escalation

Drinking plenty of water throughout the day keeps the mouth moist and may dilute unpleasant taste sensations

Your vet will advise on whether oral maintenance is appropriate for your dog

As mentioned, if not treated otherwise, duodenocutaneous fistulas exhibited poor healing (Tables 1-5 , Fig