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While perfect adherence leads to higher premium costs due to sustained drug use, even short-term GLP-1 use incurs high pharmacy spend

Glucagon receptor agonism increases resting energy expenditure, promotes hepatic fat oxidation, and drives thermogenesis

10.1056/NEJMoa066224 62 KanoskiS

The 28.7% weight loss and 82% liver fat reduction could justify this designation, particularly for MASLD, which currently has limited treatment options