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In recent years, the influence of epigenetic modifications on NRF2 has gained increasing attention, highlighting their significance in the broader context of cellular stress responses and disease progression [144,145,146]

The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)

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