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Possible mechanisms by which GMs may improve bone metabolism by the modulation of glucose and lipid metabolism include (139): GMs influence host lipid metabolism by altering bile acid composition and bile acid receptor signaling (140)

Continuous exposure to any signaling molecule can lead to receptor downregulation, meaning the body responds less strongly over time

Adults in Los Angeles with low B12, limited intake from vegan or vegetarian diets, absorption issues, or those taking metformin or acid reducers may benefit