The condition is characterised by transmural inflammation (affecting all layers of the bowel wall), which can lead to complications including strictures, fistulae, and abscesses
Otherwise, the clinical characteristics of carriers of MC4R mutations and noncarriers were broadly similar (Table 1 and Extended Data Table 2)
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comparators in a dose-dependent manner (1.3 to 5.1 mmHg with tirzepatide 5 mg, 1.7 to 6.5 mmHg with tirzepatide 10 mg, 3.1 to 11.5 mmHg with tirzepatide 15 mg) [48, 67,68,69,70]
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