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Fast forward to today, and we have the modern titans: Semaglutide (Ozempic/Wegovy) and Tirzepatide (Mounjaro/Zepbound)
Caffeine, found in coffee and many other caffeinated beverages, is known to cause a temporary increase in blood pressure, especially in people who are sensitive to its effects or consume it in large amounts
This symptom is not listed as a common adverse event in clinical trials, yet it appears frequently in real-world patient experiences
Several have active or recent FDA actions, so vetting matters
Second, targeted delivery: ligand-functionalized carriers selectively accumulate drugs in inflamed joints or renal tissues, minimizing systemic exposure and adverse effects (Yang B
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