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I would also be cautious with berberine in anyone taking medications for diabetes, blood pressure, blood thinning, or immunosuppression, because berberine may interact with several medications and could increase the risk of side effects or low blood sugar depending on the situation. People with chronic medical conditions, liver or kidney concerns, or anyone taking multiple medications should speak with their medical provider before using berberine, says Katz

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Gpna inhibits the sodium-independent transport system l for neutral amino acids

It works through the central nervous system rather than blood flow