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doi: 10.1016/0304-4165(85)90182-5 27 CozzaGRossettoMBosello-TravainVMaiorinoMRoveriAToppoSet al

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Neurons were stimulated with Dihexa or Nle'-AnglV over a 5 day period at a wide range of concentrations

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Clinical studies show that circulating Nrg4 levels in obese patients are negatively correlated with adipsin, a factor that promotes adipocyte differentiation and exacerbates lipid accumulation [106], while various exercise modalities, such as moderate-intensity continuous training, circuit resistance training, and high-intensity interval training significantly increase circulating Nrg4 levels, suggesting that it may act as a signaling mediator for exercise between adipose and liver tissues, participating in exercise-mediated improvement of metabolic dysfunction-associated steatotic liver disease (MASLD) [107]