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[15] The MTHFR gene variation is associated with a buildup of homocysteine due to impaired methylation

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Fu J, Zeng W, Chen M, Huang L, Li S, Li Z, Pan Q, Lv S, Yang X, Wang Y, Yi M et al (2022) Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1 expression in non-small cell lung carcinoma

The serving size is two capsules, which they say to take daily with 8oz of water or another beverage